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We're in the whole process of creating screening methods For added serotypes, like AAV5 and AAV9. Get in touch underneath to affix the waitlist, or to allow us to find out about other serotypes you are working with to help you us prioritize our upcoming developments.
We tried for years and established various prototypes that appreciably improved handling but were not strong sufficient or didn’t offer the desired set up changes. It wasn’t right up until lately that we arrived up with a very new design and style that satisfied all of the necessities.
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To discover resources serotype-distinct buffer formulations, we utilized a Design and style of Experiments (DOE) method of define quite possibly the most impactful attributes for that polishing step of your respective AAV purification process.
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Diverse DNA sequences that happen to be packaged throughout the viral capsid may perhaps impact the pI of the general construct. Consequently, the optimized buffer formulations were validated versus multiple sequences, as demonstrated in these figures.
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